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27612 DNA Microarray Analysis

To register for internet-transmission please see remarks

Danish title:

DNA Microarrayanalyse

Language:


Point( ECTS )


5

Course type:

MSc
Taught under open university

Schedule:

January

 

Location:

Campus Lyngby

Scope and form:

Lectures, computer exercises and project work

Duration of Course:

3 weeks

Date of examination:

Special day, the final day of the course

Type of assessment:

Evaluation:

Previous Course:

27012

Not applicable together with:

Qualified Prerequisites:

,

Participants restrictions:

Minimum 10 Maximum: 40

General course objectives:

The aim of this course is to give the students a profound knowledge of methods for microarray analysis as well as the ability to apply computerized analyses on gene expression data. Furthermore, it is a goal that the students learn to formulate interesting problems/questions that can be addressed by gene expressions analysis.

Learning objectives:

A student who has met the objectives of the course will be able to:
  • Account for the individual steps in a general microarray analysis.
  • Explain the overall theoretical principles behind the individual steps in the analysis.
  • Account for the preconditions and assumptions in the individual steps of the analysis.
  • Independently apply a basal microarray analysis.
  • Formulate problem formulations that may be answered by microarray analysis.
  • Answer the problem formulated by the students.
  • Collaborate in a group about the project work.
  • Read into and manipulate simple data structures in the statistical programming environment R.

Content:

The technology behind GeneChips and cDNA arrays; normalization of data; statistical significance of changes in gene expression; reduction and visualization of large data matrices: PCA and clustering; promoter analysis and functional analysis; integration of data; case stories and problem formulation. Finally a poster presentation based on a problem, formulated in cooperation with a group of students and the teachers.

REMARKS TO REGISTER FOR INTERNET-TRANSMISSION
To register for internet-transmission please send an e-mail to coordinator Dorthe Kjærsgaard dorthek@cbs.dtu.dk with your full name and study no. no later than 2 weeks before the ordinary application period starts (i.e. no later than November 1). After received confirmation please perform a standard application. Max 15 students on the web transmitted version.

Remarks:

The evaluated exercises/projects will be done in groups and the work done by each student must be identified, so that each student can receive and individual grade.
Exercises and the project part entail work in the statistical environment R (preknowledge is not required for onsite students. Offsite (i.e. online) students, however, are expected to be trained R users).

Green challenge participation:

Please contact the teacher for information on whether this course gives the student the opportunity to prepare a project that may participate in DTU´s Study Conference on sustainability, climate technology, and the environment (GRØN DYST). More infor http://www.groendyst.dtu.dk/english/Conference/Practical-info/Start-up

Department:

27 Department of Systems Biology

Home page:

http://www.cbs.dtu.dk/chipcourse/

Registration Sign up:

At CampusNet
Last updated: 02. maj, 2013