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27334 Bioactive compounds and nutrigenomics

Danish title:

Bioaktive stoffer og nutrigenomics


Point( ECTS )


Course type:

Taught under single-course student




Campus Lyngby

Scope and form:

Lectures, discussions of research papers, group work, reports

Duration of Course:

3 weeks

Date of examination:

Decide with teacher, No exam during the ordinary exam period

Type of assessment:



Recommended prerequisites:


General course objectives:

Please see the Danish version

Learning objectives:

A student who has met the objectives of the course will be able to:
  • Define concepts related to nutrigenomics (gene polymorphism, metagenome, epigenetics, gene transcription, proteome, and metabolome).
  • Define the term biomarkers in relation to health and disease.
  • Explain how the diet via effects on gut flora may affect the health status of the body.
  • Read scientific publications and relate critically to the presented research methods and results.
  • Employ knowledge about the immune system, biochemisty, nutrition, and diseases to present hypotheses for how nutrients and bioactive compounds can affect cell metabolism and activity (mechanism of action).
  • Combine and compare information from scientific articles to assess the efficacy of a bioactive compound.
  • Using computer-based tools analyze the potential effect of a bioactive substance on the metabolism, and from this develop a hypothesis for the mechanism of action.
  • Clearly present and support a hypothesis orally and in writing.
  • Actively participate in an academic discussion on bioactive compounds and their mechanisms of action.


The course consists of lectures and supervised project work, full time for three weeks.

The course covers the following subjects:

Gene regulation - Individual variations in response to bioactive compounds – The gut microbiota and human health - Chemical properties of bioactive compounds – Nutrigenomics methods – Biomarkers – Computer-based methods to asses bioactivity
In the first week of the course, critical reading of research articles is practiced. Weeks 2-3 of the course will mainly focus on project work concerning defined case studies including scientific writing and oral presentation by each group. Selected research literature, reviews and original papers, will be provided for the different, predefined bioactivity-nutrigenomics topics of the project work.

Green challenge participation:

Please contact the teacher for information on whether this course gives the student the opportunity to prepare a project that may participate in DTU´s Study Conference on sustainability, climate technology, and the environment (GRØN DYST). More infor http://www.groendyst.dtu.dk/english


Lars Hellgren , Building 224, Ph. (+45) 4525 2759 , lih@bio.dtu.dk


27 Department of Systems Biology

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Last updated: 17. juli, 2015