27002 Life Science
Point( ECTS )
Taught under open university
|E1B (Thurs 13-17)
For spring semester please refer to 27008.
Scope and form:
|Lectures and exercises. It is mandatory to complete two tests
during the semester to be allowed to participate in the
Duration of Course:
Type of assessment:
Not applicable together with:
General course objectives:
The students should based on the cell acquire a basic understanding
of biological processes, which are used in the industry.
Consequently, the students will acquire knowledge about the cell
structure, their biological functions, biochemical and molecular
biological processes together with biotechnological processes. With
this background the students should be able to discuss present
A student who has met the objectives of the course will be able to:
- Describe the spatial, logistic, and structural organization of
the living cell as well as the overall mechanisms and chemical
structures behind its function.
- Explain how enzymes catalyse chemical reactions and how the
overall structure and composition of proteins determines their
- Interpret results showing the effect of substrate
concentration, pH and temperature on enzyme activities, and give
examples of how both enzyme activities and metabolic pathways are
- Explain how cells oxidize glucose and use the released energy
to generate ATP, and calculate the yield of ATP from oxidation of
glucose via cellular respiration as well as by breakdown by
- Account for the antiparallel double helical structure of DNA
and the chromosomal organization in pro- and eukaryotes.
- Describe the mechanisms for bacterial cell division and
eukaryotic mitosis and meiosis and suggest how failures in the two
later processes might lead to particular geno- or phenotypes.
- Describe the Central Dogma of Molecular Biology including
replication, transcription and translation, and use the principles
along with the Genetic Code to translate a DNA sequence with or
without mutations to the corresponding amino acid sequence.
- Describe how gene expression is regulated in pro- and
eukaryotes emphasizing the many different levels this can be
- Account for the mechanisms for interbacterial transfer of
genetic material and how a virus reproduces itself by the use of
the host reproductive system.
- Master the basal terms in Mendelian genetics and apply the
principles for deducing the geno- and phenotype frequencies of the
progeny of mono- and dihybride crosses.
- Set up strategies for manipulating living cells using
recombinant DNA technology.
- Suggest appropriate biotechnological tests for examining a
particular biological question and interpret the outcome of the
The cell as basic biological unit: structure, function, metabolism,
growth, reproduction, heredity and biodiversity. The theory covers:
structure of amino acids and proteins, nucleotides and nucleic
acids, carbohydrates and lipids. Enzymes: structure, reactions,
inhibition. Dynamic biochemistry: cata- and anabolism together with
regulation of metabolism, redox processes and energy metabolism.
Synthesis of macromolecules of information: DNA and RNA, protein.
Regulation of activities in the cell e.g. synthesis of
macromolecules, responses to external stimuli. Mutation and
mutagenesis. Genetic processes in pro- and eukaryotes. Gene
technology. Examples will be given where basic biological
definitions are used in present and future biotechnology.
Sadava et al.: Life. The Science of Biology, 10. ed., vol. I, The
Cell and Heredity.
Green challenge participation:
Please contact the teacher for information on whether this course
gives the student the opportunity to prepare a project that may
participate in DTU´s Study Conference on sustainability, climate
technology, and the environment (GRØN DYST). More infor
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Last updated: 05. maj, 2014